Prognostic Factors Predicting Bleeding After Discharge Requiring Readmission After Thulium Laser Enucleation of the Prostate (ThuLEP)

  • Davide Perri
  • Andrea Pacchetti
  • Elena Morini
  • Umberto Besana
  • Giovanni Saredi
  • Antonio Luigi Pastore
  • Maria Chiara Sighinolfi
  • Bernardo Rocco
  • Salvatore Micali
  • Federica Mazzoleni
  • Carlo Buizza
  • Javier Romero-Rotero
  • Franck Bruyere
  • Thomas Herrmann
  • Giorgio Bozzini
Keywords: Bleeding, complication, haematuria, prostate enucleation, thulium laser


Objectives Postoperative haematuria is a feared complication following prostate enucleation, and it may occur
even weeks after discharge. We evaluated the risk of bleeding after discharge and its predictive factors in patients who
underwent Thulium laser enucleation of the prostate (ThuLEP).
Methods Between January 2015 and December 2018, patients with surgical indication for benign prostatic
hyperplasia underwent ThuLEP in 4 urology departments. All procedures were performed by experienced urologists.
Postoperative haematuria was defined as macroscopic haematuria occurring 7 days after discharge. Readmission
rate due to macroscopic haematuria was assessed. Logistic regression models tested for predictors of postoperative
bleeding requiring readmission.
Results Overall, 748 patients were included, and 52 (6.9%) of them were readmitted after discharge because of
macroscopic haematuria. No cases of deep venous thrombosis or pulmonary embolism were diagnosed. Mean
length of stay for surgical treatment was 2.1 days, and mean hospitalization for readmission was 5.6 days. None of
the readmitted patients required reintervention, while 46.1% of them required blood transfusions. Diabetes mellitus
(P < 0.05), a long bridge of oral anticoagulant drugs with low molecular weight heparin (LMWH) (P < 0.05) and
history of constipation (P < 0.05) were significant predictors of readmission after discharge due to macroscopic
Conclusions Patients with a clinical history of diabetes mellitus or constipation and patients who undergo a long
bridge of oral anticoagulant therapy with LMWH are at higher risk of bleeding requiring readmission after ThuLEP.

How to Cite
Perri, D., Pacchetti, A., Morini, E., Besana, U., Saredi, G., Pastore, A. L., Sighinolfi, M. C., Rocco, B., Micali, S., Mazzoleni, F., Buizza, C., Romero-Rotero, J., Bruyere, F., Herrmann, T., & Bozzini, G. (2023). Prognostic Factors Predicting Bleeding After Discharge Requiring Readmission After Thulium Laser Enucleation of the Prostate (ThuLEP). Société Internationale d’Urologie Journal, 4(5), 385-391.
Original Research